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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Alzheimers Dement. 2023 Feb 24;19(8):3537–3554. doi: 10.1002/alz.12970

Figure 4. Aberrant accumulation of CSF resident proteins in the ChP in AD.

Figure 4.

(A) Levels of CSF resident proteins in the ChP of healthy individuals and AD patients. Skyline iRT retention time prediction algorithm showing identical chromatogram retention times between proteotypic peptides used to quantify ChP proteins (right) and stable isotopically labelled synthetic peptides (left). Mean of 6 technical replicates per sample ± s.e.m.; two-sample t-test (p≤0.05).

(B) Mean intensities of NPC2 and TTR in the scanned ChP of heathy individuals and AD patients (magnification bar 100 μ). Mean of 90 technical replicates per sample ± s.e.m.; two-sample t-test (p≤0.05).

(C) Mean NPC2 and TTR intensities in the confocal images of the ChP epithelium and stroma in healthy individuals and AD (magnification bar 10 μ). Mean of 3–12 technical replicates ± s.e.m.; repeated measures (p≤0.05).

(D) Levels of ChP gangliosides in healthy individuals and AD. Mean of 6 technical replicates per sample ± s.e.m.; two-sample t-test (p≤0.05).