Table 2.
Hazard Ratios of Incident Dementia by Current Proton Pump Inhibitor Use: The Atherosclerosis Risk in Communities Study, 2011–2017
| No PPI use | PPI use | |
| # of dementia events | 434 | 151 |
| # of PYa | 22,236.7 | 7,445.6 |
| Crude IR/1000 PY (95% CI) | 19.5 (17.7–21.4) | 20.3 (17.2–23.8) |
| HR (95% CI) | No PPI use | PPI use |
| Model 1 | 1 (reference) | 1.05 (0.87–1.26) |
| Model 2 | 1 (reference) | 1.08 (0.89–1.30) |
| Model 3 | 1 (reference) | 1.09 (0.90–1.31) |
Abbreviations: APOE = Apolipoprotein E4; H2RA = H2 receptor antagonist; HR = hazard ratio; PPI = proton pump inhibitor; PY = person-years.
Model 1: adjusted for demographics (age, sex, race, center, education) + APOE4.
Model 2: adjusted for model 1 covariates + BMI.
Model 3: adjusted for model 2 covariates + hypertension, diabetes, stroke, aspirin use, and current H2RA use.
a
We calculated person-years of follow-up as time elapsed from the baseline date (visit 5) to whichever came first: dementia event, loss to follow-up, death, or administratively censored at December 2017.