Table 4.

Hazard Ratios for Incident Dementia by Cumulative Proton Pump Inhibitor Use With H2RAs as an Active Comparator, Atherosclerosis Risk in Communities Study, 2011–2017

		Exposure to proton pump inhibitors before baseline
		Any exposure	1 d - 2.8 y	>2.8–4.4 y	>4.4 y
		(n = 1,481)	(n = 451)	(n = 459)	(n = 571)
Outcome: incident dementia
	# of dementia events	165	53	48	64
Exposure to H2RAs (ref) before baseline	Any exposure	0.97 (0.70–1.35)
	1 d–2.8 y		0.80 (0.39–1.64)
	>2.8–4.4 y			1.01 (0.53–1.93)
	>4.4 y				1.02 (0.61–1.70)

Abbreviations: APOE = Apolipoprotein E4; H2RA = H₂ receptor antagonist.

All results are hazard ratios (95% CIs).

We calculated person-years of follow-up as time elapsed from the baseline date (visit 5) to whichever came first: dementia event, loss to follow-up, death, or administratively censored at December 2017.

Adjusted for age, sex, race, education, BMI, APOE4, hypertension, diabetes, stroke, and aspirin use.

H2RAs are the reference group for each analysis.