Table 1.

Summary of the literature search of variants associated with RT-induced acute inflammatory pain.

SNP	Gene	Function/Pathway	Phenotype	Sample/cancer	Number of patients	Author/year	OR	95% CI	P value
rs28419191	STING1	Inflammation/immune system	Mucositis	Blood DNA/HNC	1780	Schack et al./2022. [57]	2.27	1.70–3.05	4.4E-08
rs10875554	STING1	Inflammation/immune system	Mucositis	Blood DNA/HNC	1780	Schack et al./2022. [57]	2.25	1.68–3.01	5.1E-08
rs1131769	DNAJC18	Chaperone molecules protecting other cellular proteins	Mucositis	Blood DNA/HNC	1780	Schack et al./2022. [57]	2.21	1.66–2.95	7.6E-08
rs1265081	CCHCR1	keratinocyte proliferation or differentiation/EGFR	Mucositis	Blood DNA/HNC	500	Li et al./2021. [58]	1.41	1.08–1.86	0.012
rs3135001	HLA-DQB1	MHC class II, immune system	Mucositis	Blood DNA/HNC	500	Li et al./2021. [58]	0.53	0.35–0.79	0.002
rs117157809	TNKS	Telomere capping and maintenance and telomerase activity	Mucositis	Blood DNA/NPC	1467	Yang et al./2020. [59]	3.72	2.10–6.57	6.33E − 6
rs1799964	TNF-α	Proinflammatory cytokines	Mucositis	Blood DNA/HNC	62	Mlak et al./2020. [60]	6.61	2.14–20.40	0.001
rs1799782	XRCC1	DNA repair	Oral mucositis	Blood DNA/laryngeal cancer	150	Raturi et al./2020. [61]	6.9	1.4–34.7	0.01
rs1799782	XRCC1	DNA repair	Dermatitis	Blood DNA/laryngeal cancer	150	Raturi et al./2020. [61]	2.0	1.0–3.6	0.02
rs10898880	ATG16L2	Autophagy	Mucositis	Blood DNA/NPC	468	Yang et al./2019. [62]	1.56	1.19–2.04	0.001
rs10514231	ATG10	Autophagy	Mucositis	Blood DNA/NPC	468	Yang et al./2019. [62]	1.95	1.31–2.9	0.001
rs25487	XRCC1	DNA repair	Mucositis	Blood DNA/OPC	179	Gupta et al./2019. [63]	2.629	1.136–6.087	0.024
rs4149570	TNFRSF1A	TNF-α Proinflammatory	Mucositis	Blood DNA/HNC	58	Brzozowska et al./2018. [64]	5.625	1.584–19.975	0.008
rs1629816	GHRL	Modifier of proinflammatory cytokine activity	Mucositis	Blood DNA/HNC	65	Brzozowska et al./2018. [65]	5.92	1.58–22.22	0.008
rs4855883	APEH	Proteasome degradation	Mucositis	Blood DNA/HNC	62	Brzozowska et al./2018. [66]	0.23	0.07–0.77	0.0166
rs9344	CCND1	Cell cycle.	Mucositis	Blood DNA/NPC	154	Guo et al./2017. [67]	0.08	0.01–0.66	0.019
		NF-κB signaling
rs1800541	EDN1	Angiogenesis-related genes	Mucositis	Blood DNA/NPC	180	Ma et al./2017. [68]	2.020	1.039–3.928	0.038
rs11081899	ZNF24	DNA replication, and DNA damage response, NF-κB activation, tumor progression and angiogenesis	Mucositis	Blood DNA/NPC	33	Le et al./2017. [69]	14.631	2.61–105.46	1.2E10 − 4
rs375557	GSK3β	Wnt/β-catenin pathway	Mucositis and dermatitis	Blood DNA/NPC	188	Yu et al./2016. [70]	2.34	1.05–5.21	0.033
rs454886	APC	Wnt/β-catenin pathway	Mucositis and dermatitis	Blood DNA/NPC	188	Yu et al./2016. [70]	1.57	1.01–2.43	0.045
rs1805794	NBN	DNA damage response, DNA repair	Mucositis	Blood DNA/HNC	183	Venkatesh et al./2014. [71]	3.750	1.201–11.70	0.023
rs132788	KU70	DNA repair	Mucositis	Blood DNA/NPC	120	Ren et al./2014. [72]	3.041	1.257–7.360	0.014
rs25487	XRCC1	DNA repair	Mucositis and dermatitis	Blood DNA/NPC	114	Li et al./2013. [73]	2.65	1.04–6.73	0.037
rs25487	XRCC1	DNA repair	Mucositis	Blood DNA/HNC	101	Pratesi et al./2011. [74]	4.02	1.16–13.90	0.025
rs2067079	GAS5	Glucocorticoid receptors. Apoptosis and cell cycle.	Oral mucositis	Blood LncRNA/NPC	238	Guo et al./2017. [75]	3.031	1.014–9.055	0.047
rs6790	GAS5	Glucocorticoid receptors. Apoptosis and cell cycle.	Dermatitis	Blood LncRNA/NPC	238	Guo et al./2017. [75]	0.026	0.001–0.464	0.013

OR: Odds ratio, CI: Confidence Interval.