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. 2023 Aug 19;43:100669. doi: 10.1016/j.ctro.2023.100669

Table 4.

Summary of literature search of variants associated with RT-induced acute neuropathic pain.

SNP Gene Function/Pathway Phenotype Sample/cancer Number of patients Author/year OR 95 %CI P value
rs10950641 SNX8 Endocytosis, endosomal sorting and signaling. Glutamatergic-receptor-dependent neural plasticity Neuropathic pain DNA/HNC 1,043 Reyes-Gibby et al./2018 [76] 2.88 2.19––3.79 3.39E-14
rs6796803 KNG1 kinins act as mediators of pain and inflammation Neuropathic pain DNA/HNC 1,043 Reyes-Gibby et al/2018 [76] 0.51 0.41––0.64 6.42E-09
rs4775319 RORA Expression pattern in lamina II of SC, a region for relaying somatosensory signals of touch, temperature and pain Neuropathic pain DNA/HNC 1,043 Reyes-Gibby et al./2018 [76] 1.59 1.36––1.87 1.02E-08
rs4804217 PCP2 Neuron-specific modulator of intracellular signaling via G proteins Neuropathic pain DNA/HNC 1,043 Reyes-Gibby et al./2018 [76] 0.58 0.48––0.69 2.95E-09