Table 4.

Summary of literature search of variants associated with RT-induced acute neuropathic pain.

SNP	Gene	Function/Pathway	Phenotype	Sample/cancer	Number of patients	Author/year	OR	95 %CI	P value
rs10950641	SNX8	Endocytosis, endosomal sorting and signaling. Glutamatergic-receptor-dependent neural plasticity	Neuropathic pain	DNA/HNC	1,043	Reyes-Gibby et al./2018 [76]	2.88	2.19––3.79	3.39E-14
rs6796803	KNG1	kinins act as mediators of pain and inflammation	Neuropathic pain	DNA/HNC	1,043	Reyes-Gibby et al/2018 [76]	0.51	0.41––0.64	6.42E-09
rs4775319	RORA	Expression pattern in lamina II of SC, a region for relaying somatosensory signals of touch, temperature and pain	Neuropathic pain	DNA/HNC	1,043	Reyes-Gibby et al./2018 [76]	1.59	1.36––1.87	1.02E-08
rs4804217	PCP2	Neuron-specific modulator of intracellular signaling via G proteins	Neuropathic pain	DNA/HNC	1,043	Reyes-Gibby et al./2018 [76]	0.58	0.48––0.69	2.95E-09