Table 5.
Summery of literature search of variants associated with other mixed types of RT-induced acute pain.
| SNP | Gene | Pathway | Phenotype | Sample/cancer | Number of patients | Author/year | OR | 95% CI | P value |
|---|---|---|---|---|---|---|---|---|---|
| rs1800629 | TNFα | NF-κβ pathway, (Inflammation) | Neck pain/throat pain | DNA/Thyroid cancer | 203 | Liu et al./2018. [77] | 10.3 | 2.7–39.1 | 0.001 |
| rs11212570 | ATM | DNA damage response (DDR) | Throat pain | DNA/Thyroid cancer | 203 | Liu et al./2018. [77] | 4.3 | 1.4–13.1 | 0.01 |
| rs230493 | NF-κβ | Inflammation | Throat pain | DNA/Thyroid cancer | 203 | Liu et al./2018. [77] | 0.2 | 0.1–1.0 | <0.05 |
| rs1800469 | TGF-β | Cell growth, cell differentiation, vascular regeneration and apoptosis | Throat pain | DNA/Thyroid cancer | 203 | Liu et al./2018. [77] | 5.543 | 1.1–28.8 | 0.04 |
| rs2241716 | TGF-β | Cell growth, cell differentiation, vascular regeneration and apoptosis | Throat pain | DNA/Thyroid cancer | 203 | Liu et al./2018. [77] | 6.1 | 1.5–25.6 | 0.01 |