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[Preprint]. 2024 Feb 17:2023.10.19.563168. Originally published 2023 Oct 23. [Version 2] doi: 10.1101/2023.10.19.563168

Figure 8. Microglial depletion during abstinence does not affect context-induced drug-seeking.

Figure 8.

A). Experimental timeline. B) METH intake and infusions earned during 15 daily 2-hr sessions. C) Active and inactive lever presses. Two-way RM ANOVA with Bonferroni’s post-hoc test, (Active vs Inactive Lever, ****p < .0001). D) Active lever presses for Maintenance (Maint: average final 3 days) and Drug-Seeking (Seek) of AIN-76A and PLX5622. Two-way RM ANOVA with Bonferroni post-hoc test (AIN-76A Maint vs Seek, *p < .05; PLX5622 Maint vs Seek, *p < .05; AIN-76A vs PLX5622 Seek, p = .8). E) Active and inactive lever presses during Drug-Seeking session. Two-way ANOVA with Bonferroni’s post-hoc test (Active vs Inactive Lever, ***p < .001, AIN-76A vs PLX5622 Active Lever, p = .853). AIN-76A (n = 9), PLX5622 (n = 9). Data are represented as mean ± SEM.