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[Preprint]. 2023 Oct 24:2023.10.22.563461. [Version 1] doi: 10.1101/2023.10.22.563461

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Figure 4. — Characterization of the 119 A1-LCD swap variants selected by designing for more compact conformational ensembles and the wild-type (WT) A1-LCD. We show the relationship between R_g and (a) k, (b) ω_aro (patterning of aromatic residues; a high ω_aro indicates clustering of aromatic residues), (c) the c_sat calculated from simulations of 100 chains in slab geometry. We highlight the WT sequence of A1-LCD in green and five variants selected for experimental characterization in red. Error bars of the average R_g are not shown as their size is negligible.