Figure 4. The effect of proteotoxic bacteria on proteins associated with neurodegenerative diseases.
A) The effect of gram-negative, aerobic bacteria on C. elegans intestinal polyQ aggregation (“Aggregates”) and the associated toxicity (“Motility”). Three robust enhancers of polyQ aggregation were tested using intestinal polyQ, B) neuronal polyQ, C) muscle polyQ, D) muscle Aβ1–42, and E) muscle α-synuclein. Data are represented as the average number of aggregates or TOP (seconds) per worm obtained from at least two independent experiments for a total of 30–60 worms. Error bars represent SEM. Statistical significance was calculated using one-way ANOVA followed by multiple comparison Dunnett’s post-hoc test (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).