Table 1–1. Male-only sternomastoid NMJ morphometry data across lifespan.
Data for each timepoint studied presented as: Median value (interquartile range). Sample sizes (animals and synapses) indicated for each timepoint.
| Age | P14 | P21 | ||
|---|---|---|---|---|
| Genotype | WT | ΔIg3-MuSK | WT | ΔIg3-MuSK |
| Nerve Terminal Area (μm 2 ) | 134.374 (108.17, 169.624) | 135.632 (108.061, 170.442) | 155.226 (133.552, 181.631) | 162.096 (143.183, 204.451) |
| AChR Area (μm2) | 174.074 (135.389, 211.237) | 202.719 (145.052, 250.194) | 207.802 (173.411, 247.451) | 222.007 (176.808, 278.327) |
| Endplate Area (μm2) | 249.85 (200.152, 315.087) | 289.332 (213.942, 350.153) | 321.944 (269.604, 396.63) | 372.687 (294.528, 465.446) |
| Compactness | 0.685 (0.627, 0.737) | 0.703 (0.653, 0.759) | 0.635 (0.59, 0.696) | 0.607 (0.566, 0.67) |
| Fragmentation | 1 (1, 1) | 1 (1, 1) | 2 (1, 3) | 3 (2, 4) |
| N NMJs) | 103 | 77 | 85 | 82 |
| N (animals) | 6 M | 5 M | 6 M | 6 M |
| Age | P30 | 3 months | ||
| Genotype | WT | ΔIg3-MuSK | WT | ΔIg3-MuSK |
| Nerve Terminal Area (μm2) | 242.712 (194.96, 303.927) | 231.833 (177.882, 265.737) | 324.85 (256.83, 404.88) | 283.90 (224.97, 359.78) |
| AChR Area (μm2) | 310.453 (268.522, 373.865) | 283.402 (230.952, 330.542) | 440.97 (351.43, 499.85) | 359.27 (278.03, 446.45) |
| Endplate Area (μm2) | 599.541 (475.166, 742.781) | 579.201 (431.658, 690.198) | 965.78 (794.17, 1238.18) | 834.11 (624.07, 1117.29) |
| Compactness | 0.528 (0.49, 0.588) | 0.496 (0.457, 0.546) | 0.433 (0.395, 0.478) | 0.429 (0.353, 0.487) |
| Fragmentation | 3 (2, 5) | 5 (3, 8) | 6 (3, 8) | 6 (5, 9) |
| N (NMJs) | 61 | 89 | 77 | 80 |
| N (Animals) | 5 M | 7 M | 6 M | 6 M |
| Nerve terminal caliber (Fig. 3) | NA | NA | 2.187 (2.01, 2.726) | 2.375 (2.026, 2.541) |
| Age | 14 months | 2 Years | ||
| Genotype | WT | ΔIg3-MuSK | WT | ΔIg3-MuSK |
| Nerve Terminal Area (μm2) | 288.367 (216.764, 347.376) | 238.753 (173.655, 334.442) | 265.435, (214.067, 351.285) | 275.408, (208.403, 354.959) |
| AChR Area (μm2) | 371.013 (277.396, 500.124) | 345.33 (224.661, 467.449) | 343.954, (280.852, 434.392) | 365.561, (291.658, 468.384) |
| Endplate Area (μm2) | 926.124 (580.3, 1214.764) | 716.36 (556.243, 1176.327) | 778.891, (541.145, 1122.401) | 870.286, (623.292, 1152.434) |
| Compactness | 0.429 (0.384, 0.507) | 0.455 (0.359, 0.499) | 0.454 (0.383, 0.514) | 0.411 (0.354, 0.468) |
| Fragmentation | 5 (3, 6.5) | 6 (5, 9) | 5 (4, 7) | 7 (4, 10) |
| N (NMJs) | 63 | 53 | 53 | 86 |
| N (animals) | 5 M | 5 M | 5 M | 7 M |