Extended Data Figure 8: In-vivo validation of MT isoform expression from an unrelated autism NRXN1^+/− patient.

(a) Schematic of novel NRXN1 autism patient, and GOF therapeutic targeting pipeline, with (b) schematic of the NRXN1α isoform structures, with each row representing a unique NRXN1α isoform and each column representing a NRXN1 exon. The colored isoforms (navy, wildtype; peach, patient-specific) are spliced into the transcript while the blank exons are spliced out. (c) The abundance of each NRXN1α isoform by sample.