Figure 1. Spike shape regulates I_NaP-dependent intrinsic bursting.

(A) Schematic diagram of a model neuron with modifiable spike shape. (B) Example spike shapes and (C) quantification of spike height and AHP during increasing g_SPK or g_AHP. (D) Voltage traces of an average intrinsic burster (g_NaP = 3.33 nS and g_leak = 3.5 nS (Koizumi and Smith, 2008)) illustrating how increasing g_SPK or g_AHP changes the activity pattern (silent, bursting, or tonic) produced as g_Tonic is varied. (E) Activity patterns as a function of g_Tonic and g_SPK (left) or g_AHP (right). Notice that for small increases in g_SPK or g_AHP, intrinsic bursting (red shaded region) is lost and the neuron is rendered ’burst-incapable’. (F) burst-capable regions of g_Leak, g_NaP space as g_SPK (left) or g_AHP (right) is increased. White dot indicates g_Leak, g_NaP values of neuron in D & E.