Figure 4. Selective block of I_NaP in burst-capable or burst-incapable neurons has similar consequences for rhythm generation.

(A) Distributions of g_NaP and g_Leak among burst-capable (red) and incapable (black) neurons in a network with g_SPK = 6 nS. (B) Prevalence of silent, bursting, and tonic intrinsic cellular activities with overlaid network firing rate during increasing g_Tonic in the same network. (C1-3) Comparison of global I_NaP block (C1) vs. progressive I_NaP block specifically in neurons that are initially burst-capable (C2) or burst-incapable (C3). (D1-3) Fraction of the network that is burst-capable and amount of I_NaP remaining as a function of I_NaP block progression. (E1-3) Parameter space supporting intrinsic bursting (red) and network rhythmogenesis (white) as a function of excitability (g_Tonic) during progressive I_NaP block. (F1-F3) Raster plots and overlaid network firing rate corresponding to points 1-10 shown in E1-3.