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[Preprint]. 2023 Nov 4:2023.11.01.565163. [Version 1] doi: 10.1101/2023.11.01.565163

Figure 5. Sexually dimorphic response of Ctrp10-KO mice to an obesogenic diet.

Figure 5.

(A) Body weights over time of WT and KO male mice fed a high-fat diet (HFD). (B) Body composition analysis of WT (n = 17) and KO (n = 14) male mice fed a HFD for 9 weeks. (C-E) Food intake, physical activity, and energy expenditure in male mice across the circadian cycle (light and dark) and metabolic states (ad libitum fed, fasted, refed) (WT, n = 11; KO, n = 11). Indirect calorimetry analysis was performed after male mice were on HFD for 10 weeks. (F) Body weights over time of WT and KO female mice fed a high-fat diet. (G) Representative image of WT and KO female mice after 13 weeks of high-fat feeding. (H) Body composition analysis of WT (n = 17) and KO (n = 13) female mice on HFD for 6 weeks. (I-K) Food intake, physical activity, and energy expenditure in female mice (WT, n = 11-12; KO, n = 12) across the circadian cycle (light and dark) and metabolic states (ad libitum fed, fasted, refed). Indirect calorimetry analysis was performed after female mice were on HFD for 6 weeks. (L) ANCOVA analysis of energy expenditure using body weight as a covariate. (M) Respiratory exchange ratio (RER). All data are presented as mean ± S.E.M. * P < 0.05; ** P < 0.01; *** P < 0.001; **** P < 0.0001