Table 5.

Adjusted Multinomial Logistic Regression Models Testing the Association between Demographics, Underlying Health Conditions, and COVID-Related Characteristics with Disease Severity

	Moderate1			Severe1			Death1
Variable	aOR2	95% CI2	p	aOR2	95% CI2	p	aOR2	95% CI2	p
Demographics
Age	1.05	1.03, 1.06	<0.001	1.05	1.03, 1.07	<0.001	1.09	1.05, 1.13	<0.001
Male	1.28	0.89, 1.85	0.18	1.34	0.82, 2.19	0.24	1.21	0.52, 2.81	0.66
White	0.70	0.46, 1.06	0.09	0.89	0.51, 1.54	0.67	0.73	0.27, 1.96	0.53
Underlying Conditions
Chronic Lung Disease	2.10	1.38, 3.17	<0.001	1.98	1.15, 3.41	0.01	1.31	0.50, 3.46	0.58
Hypertension	1.02	0.65, 1.59	0.94	0.97	0.53, 1.76	0.91	3.46	0.88, 13.57	0.08
Overweight	1.40	0.95, 2.07	0.09	1.17	0.69, 1.99	0.56	1.61	0.65, 4.01	0.30
Cardiovascular Disease	1.63	1.06, 2.50	0.03	1.45	0.82, 2.55	0.20	1.08	0.44, 2.63	0.87
Diabetes	0.99	0.64, 1.54	0.98	1.45	0.83, 2.54	0.20	1.09	0.43, 2.74	0.86
Renal Disease	2.64	1.61, 4.32	<0.001	1.91	1.01, 3.64	0.05	3.63	1.41, 9.36	0.01
Liver Disease	1.13	0.48, 2.69	0.78	1.84	0.69, 4.92	0.22	1.48	0.25, 8.78	0.67
Autoimmune Disease	1.78	0.87, 3.65	0.11	1.95	0.77, 4.95	0.16	3.96	1.00, 15.65	0.05
Immunocompromised3	1.08	0.55, 2.11	0.82	0.59	0.25, 1.40	0.23	3.26	0.83, 12.71	0.09
Systemic Immunosuppressive Therapy or Meds.	3.45	1.88, 6.32	<0.001	5.01	2.38, 10.51	<0.001	1.48	0.38, 5.71	0.57
Days Since Most Recent Vaccination/Booster
Unvaccinated	Ref	—		Ref	—		Ref	—
Within past 90 Days 4	0.37	0.16, 0.88	0.02	0.40	0.13, 1.26	0.12	0.72	0.18, 2.86	0.64
91 – 180 Days Ago 4	0.32	0.19, 0.54	<0.001	0.42	0.21, 0.82	0.01	0.31	0.10, 0.96	0.04
181 – 270 Days Ago 4	0.32	0.18, 0.56	<0.001	0.38	0.17, 0.80	0.01	0.14	0.04, 0.59	0.01
More than 270 Days4 Ago	0.53	0.23, 1.21	0.13	0.88	0.34, 2.29	0.79	0.34	0.06, 1.95	0.23
Lineage
Delta	Ref	—		Ref	—		Ref	—
Omicron5	0.95	0.61, 1.47	0.81	1.42	0.81, 2.50	0.22	2.07	0.84, 5.12	0.12

¹”Mild” is the Reference Category

²aOR = Adjusted Odds Ratio, CI = Confidence Interval, Ref = Reference Level

³HIV infection, active cancer, solid organ transplant, hematopoietic stem cell transplant

⁴Compared to unvaccinated individuals

⁵Compared to Delta