Table 1.

Lead genetic variants, effect sizes, allele frequencies, and mapped genes at loci reach genome wide significance for coronary artery dominance status.

Genomic Locus No	GIA	GWAS Analysis	chr	snp rsID	bp hg38/GRCh38	bp hg19/GRCh37	Allele1	Allele2	AF Allele2	BETA	SE	OR (95%CIs)	p.value	AF case	AF ctrl	N_case	N_ctrl	N	Mapped Genes
1	AFR	RvsL	3	rs544905040	2757792	2841160	A	G	0.005	1.33	0.25	3.8 (2.33–6.2)	4.71E-08	0.013	0.004	1167	8280	9447	CNTN4, CNTN6
2	AMR	RvsLCo	3	rs9873160	197417938	197144809	G	C	0.073	0.56	0.10	1.75 (1.43–2.14)	1.82E-08	0.108	0.066	738	3717	4455	DLG1
3	EUR	RvsLCo	4	rs56410855	173452142	174373293	G	T	0.094	0.17	0.03	1.19 (1.12–1.26)	2.32E-09	0.107	0.091	7708	37613	45321	SCRG1, HMGB2, FBXO8, CEP44
3	EUR	RvsL	4	rs56410855	173452142	174373293	G	T	0.094	0.21	0.04	1.24 (1.15–1.33)	1.03E-09	0.111	0.091	4944	37613	42557	SCRG1, HMGB2, FBXO8, CEP44
3	ALL	RvsL	4	rs78510568/rs748824055	173475861	174397012	C	T	0.078	0.21	0.03	1.24 (1.16–1.32)	1.95E-10	0.092	0.076	6640	50405	57045	SCRG1, HMGB2, FBXO8, CEP44
3	ALL	RvsLCo	4	rs112133513	173487900	174409051	G	A	0.081	0.17	0.03	1.19 (1.12–1.25)	3.40E-10	0.090	0.079	10638	50405	61043	SCRG1, HMGB2, FBXO8, CEP44
4	ALL	RvsLCo	5	rs567007743	99585888	98921592	A	G	0.002	0.67	0.15	1.95 (1.45–2.63)	5.05E-06	0.003	0.002	10638	50405	61043	ELL2, PCSK1, ERAP1, ERAP2, LNPEP, LIX1, RIOK2, RGMB,CHD1, FAM174A, ST8SIA4, SLCO4C1
5	EUR	RvsLCo	5	rs954635	173220844	172647847	A	T	0.282	0.15	0.02	1.16 (1.11–1.2)	1.46E-13	0.306	0.277	7708	37613	45321	SH3PXD2B, NEURL1B, DUSP1, ERGIC1, ATP6V0E1,CREBRF, BNIP1, NKX2–5, C5orf47, MSX2
5	ALL	RvsLCo	5	rs954635	173220844	172647847	A	T	0.362	0.11	0.02	1.12 (1.08–1.16)	3.03E-11	0.389	0.357	10638	50405	61043	SH3PXD2B, NEURL1B, DUSP1, ATP6V0E1, CREBRF, BNIP1,NKX2–5, C5orf47, MSX2
5	EUR	RvsL	5	rs62385088	173222031	172649034	G	A	0.164	0.21	0.03	1.23 (1.17–1.3)	1.09E-13	0.190	0.161	4944	37613	42557	SH3PXD2B, NEURL1B, DUSP1, ATP6V0E1, CREBRF, BNIP1,NKX2–5, C5orf47, MSX2
5	ALL	RvsL	5	rs55893552	173223617	172650620	T	A	0.158	0.17	0.03	1.18 (1.12–1.24)	3.79E-11	0.175	0.156	6640	50405	57045	SH3PXD2B, NEURL1B, DUSP1, ATP6V0E1, CREBRF, BNIP1,NKX2–5, C5orf47, MSX2
6	ALL	RvsL	10	rs2902339	44018658	44514106	G	A	0.784	−0.24	0.02	0.79 (0.75–0.82)	5.14E-28	0.746	0.788	6640	50405	57045	HNRNPF,ZNF239, ZNF485, ZNF32, CXCL12, TMEM72,RASSF4, C10orf10, C10orf25, ZNF22, ALOX5, NPY4R
6	EUR	RvsL	10	rs7917534	44041975	44537423	G	C	0.798	−0.25	0.03	0.78 (0.74–0.82)	1.29E-21	0.762	0.803	4944	37613	42557	HNRNPF,ZNF239, ZNF485, ZNF32, CXCL12, TMEM72,RASSF4, C10orf10, C10orf25, ZNF22, ALOX5, NPY4R
6	EUR	RvsLCo	10	rs589655	44249867	44745315	C	G	0.100	0.31	0.03	1.37 (1.3–1.45)	4.37E-29	0.126	0.095	7708	37613	45321	HNRNPF, ZNF239, ZNF485, ZNF239, ZNF485, ZNF32,CXCL12, TMEM72, RASSF4, C10orf10, C10orf25, ZNF22,ALOX5, NPY4R
6	AFR	RvsL	10	rs2576354	44254945	44750393	G	A	0.259	0.32	0.05	1.37 (1.25–1.51)	9.21E-11	0.317	0.251	1167	8280	9447	ZNF485, ZNF32, CXCL12, TMEM72, RASSF4, C10orf10,C10orf25, ZNF22, ALOX5, NPY4R
6	AFR	RvsLCo	10	rs2576354	44254945	44750393	G	A	0.262	0.27	0.04	1.3 (1.21–1.41)	1.17E-11	0.305	0.251	2040	8280	10320	HNRNPF, ZNF485, ZNF32, CXCL12, TMEM72, RASSF4,C10orf10, C10orf25, ZNF22, NPY4R
6	ALL	RvsLCo	10	rs606314	44255031	44750479	C	G	0.101	0.30	0.02	1.36 (1.29–1.42)	6.58E-37	0.126	0.096	10638	50405	61043	RASGEF1A, HNRNPF, ZNF239, ZNF485, ZNF32, CXCL12,TMEM72, RASSF4, C10orf10, C10orf25, ZNF22, ALOX5,NPY4R
7	ALL	RvsL	10	rs1194743	52452837	54212597	T	C	0.779	0.15	0.02	1.17 (1.11–1.22)	2.44E-10	0.802	0.776	6640	50405	57045	A1CF, PRKG1, DKK1
7	EUR	RvsL	10	rs1194743	52452837	54212597	T	C	0.747	0.15	0.03	1.16 (1.1–1.23)	7.51E-09	0.770	0.744	4944	37613	42557	A1CF, PRKG1, DKK1
8	ALL	RvsL	11	rs35342212/rs67428213	15874288	15895834	G	A	0.229	−0.13	0.02	0.87 (0.83–0.92)	1.05E-08	0.206	0.232	6640	50405	57045	INSC, SOX6, C11orf58
8	ALL	RvsLCo	11	rs35342212/rs67428213	15874288	15895834	G	A	0.228	−0.11	0.02	0.9 (0.86–0.93)	7.43E-09	0.208	0.232	10638	50405	61043	INSC, SOX6, C11orf58
9	ALL	RvsL	15	rs58473469	174592722	174885063	C	T	0.200	−0.16	0.03	0.85 (0.81–0.9)	9.75E-10	0.183	0.202	6640	50405	57045	ADPGK, C15orf60, LOXL1, STOML1, PML, STRA6, CCDC33, CYP11A1, SEMA7A, UBL7, ARID3B, CLK3, CYP1A1,CYP1A2, CSK, LMAN1L, ULK3, SCAMP2, FAM219B, COX5A,RPP25, SCAMP5, GOLGA6D, COMMD4, NEIL1, SNUPN
10	ALL	RvsLCo	17	rs851058	43760351	41837719	G	A	0.391	0.09	0.02	1.09 (1.06–1.13)	1.40E-08	0.405	0.388	10638	50405	61043	AOC2, ARL4D, DHX8, ETV4, SOST, DUSP3, C17orf105,MPP3, CD300LG, MPP2, NAGS, G6PC3
10	EUR	RvsLCo	17	rs851058	43760351	41837719	G	A	0.417	0.11	0.02	1.11 (1.07–1.15)	4.54E-09	0.438	0.413	7708	37613	45321	AOC2, ARL4D, DHX8, ETV4, SOST, DUSP3, C17orf105,MPP3, CD300LG, MPP2, NAGS

Genomic locus No: Index of genomic risk loci, GIA: Genetically inferred ancestry (ALL; all ancestral groups combined, EUR; genetically inferred European subjects, AFR; genetically inferred African subjects, AMR; genetically inferred Admixed-Americans), GWAS: Genome-wide assocociation analysis comparison (RvsLCo; right dominance as reference versus left and co-dominant subjects combined, RvsL; right dominance (reference) versus left dominance subjects excluding subjects with mixed dominance, chr: chromosome, SNP rsID: variant ID, bp hg38/GRCh38: base position on human build 38, bp hg19/GRCh37: base position on human build 37, Allele1: allele 1, Allele2: allele 2, AF_Allele2: allele frequency of allele 2, BETA: effect size of allele 2, SE: standard error of BETA, OR (95%CIs): Odds ratio and 95% confidence intervals of non-right dominance to right dominance for allele 2 compared to allele1, p.value: p value with SaddlePoint Approximation applied, AF_case: allele frequency of allele 2 in cases, AF_ctrl: allele frequency of allele 2 in controls, N_case: sample size in cases, N_ctrl: sample size in controls, N: sample size cases and controls combined. Mapped genes include either by position (ANNOVAR), gene expression (eQTL), or chromatin interaction. Genes mapped by all three methods are bolded.