Table 1.
CSF Module Quantitative Trait Loci.
| SNP | CHR | BP | A1 | Nearest Coding Gene to SNP | BETA | P value | Module | mod-QTL | Significant after GC Correction* |
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| rs429358 | 19 | 45411941 | C | APOE | −0.07 | 1.0E-52 | M33 Oxidant Detoxification/MAPK Signaling | trans | yes |
| rs429358 | 19 | 45411941 | C | APOE | −0.05 | 1.3E-27 | M26 Neddylation | trans | yes |
| rs10819083 | 9 | 128660207 | C | PBX3 | −0.03 | 1.1E-08 | M32 LICAM/Axon Development | trans | yes |
| rs13409992 | 2 | 16575331 | T | CYRIA | −0.05 | 1.4E-08 | M9 Ambiguous | trans | yes |
| rs429358 | 19 | 45411941 | C | APOE | 0.07 | 7.0E-64 | M34 Mitochondrion | trans | yes |
| rs6442288 | 3 | 11847081 | T | TAMM41 | 0.05 | 4.5E-08 | M13 Immunoglobulins | trans | no |
| rs539717210 | 7 | 23347402 | A | MALSU1 | 0.06 | 4.8E-08 | M16 Ambiguous | trans | no |
| rs11745580 | 5 | 149378425 | T | TIGD6 | 0.04 | 2.9E-08 | M27 Nucleosome | trans | no |
| rs2887087 | 2 | 33695073 | T | RASGRP3 | 0.02 | 3.5E-09 | M20 Glycolysis/Redox Homeostasis | trans | yes |
| rs736334 | 22 | 51139178 | T | SHANK3 | 0.03 | 2.8E-08 | M25 Ambiguous | trans | No |
SNP, single nucleotide polymorphism; CHR, chromosome; BP, base pair; A1, allele; mod-QTL, module quantitative trait locus; GC, genomic control.
*
”Yes” indicates genome-wide significant level at p<5 × 10−8