Table 3.
P estimates and 95% confidence intervals corresponding to percentage change in bioactive lipids associated (p ≤ 0.05) with a doubling in PFAS; for joint cohort and meta-analyses.
| All 3 cohorts, random intercept (N = 387) | CiOB & IKIDS, random intercept (N = 347) | All 3 cohorts, meta-analysis (N = 387) | CiOB & IKIDS, meta-analysis (N = 347) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| ||||||||||||||
| Bioactive Lipid Pathway/Group | Lipid | PFAS | β | 95% CI lower | 95% CI upper | β | 95% CI lower | 95% CI upper | β | 95% CI lower | 95% CI upper | β | 95% CI lower | 95% CI upper |
|
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| Cyclooxygenase | 13,14-D-PGJ2 | Me-PFOSA-AcOH | - | - | - | - | - | - | - | - | - | 3.8 | 0.1 | 7.7 |
| Cyclooxygenase | 13,14DHK-PGF2a* | PFNA | 10.6 | 1.6 | 20.4 | 10.4 | 1.7 | 20.0 | - | - | - | - | - | - |
| Cyclooxygenase | 13,14DHK-PGF2a* | PFUdA | - | - | - | 6.8 | 2.4 | 11.5 | - | - | - | 6.4 | 1.9 | 11.1 |
| Cyclooxygenase | 9-oxoODE | PFNA | - | - | - | −2.4 | −4.6 | −0.1 | −2.28 | −4.24 | −0.29 | −2.3 | −4.3 | −0.3 |
| Cyclooxygenase | BCPGE1 | PFNA | 12.8 | 2.9 | 23.6 | 10.3 | 0.3 | 21.3 | 11.57 | 1.79 | 22.29 | 10.6 | 0.6 | 21.7 |
| Cyclooxygenase | BCPGE1 | PFOA | - | - | - | 11.8 | 1.6 | 23.1 | - | - | - | 11.6 | 1.4 | 22.9 |
| Cyclooxygenase | PGD2 | PFDeA | - | - | - | - | - | - | - | - | - | 13.2 | 1.4 | 26.4 |
| Cyclooxygenase | PGD2 | PFNA | 16.5 | 1.9 | 33.1 | - | - | - | 15.6 | 2.2 | 30.8 | - | - | - |
| Cyclooxygenase | PGD2 | PFOA | - | - | - | 24.3 | 7.3 | 43.9 | - | - | - | 21.7 | 7.3 | 38.1 |
| Cyclooxygenase | PGD2 | PFOS | 11.9 | 0.4 | 24.7 | - | - | - | 16.6 | 5.6 | 28.8 | 17.0 | 5.8 | 29.3 |
| Cyclooxygenase | PGD3 | PFOS | 11.5 | 1.5 | 22.5 | 10.4 | 0.4 | 21.4 | 10.0 | 1.2 | 19.6 | - | - | - |
| Cyclooxygenase | PGD3 | PFUdA | - | - | - | 10.3 | 3.5 | 17.6 | - | - | - | - | - | - |
| Cyclooxygenase | PGE3 | PFNA | 13.8 | 1.2 | 28.1 | - | - | - | - | - | - | - | - | - |
| Cyclooxygenase | PGE3 | PFOA | - | - | - | 16.3 | 2.6 | 31.9 | - | - | - | 15.6 | 2.2 | 30.7 |
| Cyclooxygenase | TXB2 | Me-PFOSA-AcOH | - | - | - | 5.4 | 0.2 | 10.8 | - | - | - | 5.4 | 0.2 | 10.9 |
| Cytochrome p450 | 13,14DHK-PGD2 | Me-PFOSA-AcOH | - | - | - | 5.2 | 0.5 | 10.2 | - | - | - | - | - | - |
| Cytochrome p450 | 14(15)-EET | PFDeA | - | - | - | 6.4 | 1.0 | 12.0 | - | - | - | 6.6 | 1.3 | 12.2 |
| Cytochrome p450 | 20-HETE | PFNA | 6.9 | 0.5 | 13.6 | - | - | - | - | - | - | - | - | - |
| Cytochrome p450 | 5(6)-EET | PFOA | - | - | - | - | - | - | - | - | - | 20.6 | 4.4 | 39.3 |
| Cytochrome p450 | 5(6)-EET | PFUdA | - | - | - | 9.3 | 0.9 | 18.5 | - | - | - | - | - | - |
| Cytochrome p450 | 8(9)-EET | Me-PFOSA-AcOH | - | - | - | 5.4 | 0.9 | 10.0 | - | - | - | 5.8 | 1.5 | 10.2 |
| Cytochrome p450 | 8,9-DHET | PFNA | - | - | - | 6.9 | 0.3 | 13.8 | - | - | - | - | - | - |
| Cytochrome p450 | 8,9-DHET | PFUdA | - | - | - | 3.6 | 0.2 | 7.1 | - | - | - | - | - | - |
| Lipoxygenase | 12-oxoETE | PFDeA | - | - | - | 8.0 | 1.6 | 14.8 | - | - | - | 7.9 | 1.4 | 14.7 |
| Lipoxygenase | 12-oxoETE | PFNA | 10.1 | 1.9 | 19.0 | - | - | - | 8.7 | 0.8 | 17.3 | - | - | - |
| Lipoxygenase | 12-oxoETE | PFOS | 8.2 | 1.8 | 15.0 | 7.2 | 1.2 | 13.5 | 7.4 | 1.4 | 13.9 | 7.1 | 1.0 | 13.5 |
| Lipoxygenase | 12-oxoETE | PFUdA | - | - | - | 5.9 | 1.7 | 10.2 | - | - | - | 5.9 | 1.7 | 10.3 |
| Lipoxygenase | 15-HETE | PFHxS | - | - | - | −7.8 | −13.6 | −1.5 | - | - | - | −7.5 | −13.5 | −1.2 |
| Lipoxygenase | 15-oxoETE | PFDeA | - | - | - | 8.5 | 1.6 | 15.8 | - | - | - | 7.5 | 0.7 | 14.8 |
| Lipoxygenase | 15-oxoETE | PFOA | - | - | - | 9.6 | 1.0 | 19.0 | - | - | - | 9.1 | 0.6 | 18.2 |
| Lipoxygenase | 15-oxoETE | PFOS | 10.3 | 1.9 | 19.3 | 10.4 | 3.9 | 17.4 | 10.3 | 3.8 | 17.3 | 10.3 | 3.8 | 17.2 |
| Lipoxygenase | 15-oxoETE | PFUdA | - | - | - | 6.5 | 2.1 | 11.2 | - | - | - | 6.0 | 1.5 | 10.7 |
| Lipoxygenase | 5-HETE | PFDeA | - | - | - | 6.7 | 1.5 | 12.1 | - | - | - | 5.8 | 0.6 | 11.3 |
| Lipoxygenase | RVD2 | PFUdA | - | - | - | 7.3 | 1.9 | 13.0 | - | - | - | 6.8 | 1.3 | 12.6 |
| Parent Compound | AA | PFNA | 10.9 | 3.0 | 19.4 | 10.6 | 2.9 | 19.0 | 9.5 | 2.3 | 17.3 | 8.7 | 1.4 | 16.6 |
| Parent Compound | AA | PFOS | 9.7 | 3.4 | 16.3 | 9.1 | 3.2 | 15.3 | 8.2 | 2.5 | 14.2 | 8.0 | 2.3 | 14.0 |
| Parent Compound | EPA | PFUdA | - | - | - | 3.7 | 0.3 | 7.2 | - | - | - | 3.8 | 0.2 | 7.4 |
| Parent Compound | LA | PFOA | - | - | - | 11.4 | 0.1 | 24.0 | - | - | - | - | - | - |
| Parent Compound | LA | PFUdA | - | - | - | 6.6 | 1.0 | 12.6 | - | - | - | 7.9 | 2.0 | 14.2 |
| Parent Compound | αLA | PFUdA | - | - | - | −4.9 | −9.1 | −0.5 | - | - | - | - | - | - |