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[Preprint]. 2023 Nov 4:2023.11.03.23298055. [Version 1] doi: 10.1101/2023.11.03.23298055

Figure 3. Cumulative Hazard of Incident CAD by Clinical and Genomic Risk in Three Age Groups.

Figure 3.

In the UK Biobank (N=327,837), three age groups (<55, 55–65 and over 65 years) at risk estimation were used to compare the cumulative incidence of CAD by genomic (PRS) and clinical (PCE) risk levels defined as low (bottom quintile), intermediate (middle three quintiles), and high (top quintile) within each age group. We report the cumulative hazard over the observed follow-up time (median 12.2 years). The stratification was highest in the <55 years age group (A), where the cumulative hazard ranged from 0.45% (95% CI 0.23–0.67) for individuals with low PRS and low PCE to 14.6% (95% CI 12.8–15.5) for individuals with high PRS and high PCE. The stratification decreased but persisted in the older age groups (B and C). Here we feature the same Y axis to emphasize differences in absolute risk among young, middle and older individuals.

CAD: coronary artery disease, PRS: polygenic risk score, PCE: Pooled Cohort Equations.