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[Preprint]. 2023 Nov 4:2023.11.03.23298055. [Version 1] doi: 10.1101/2023.11.03.23298055

Figure 4. Augmenting Risk Prediction of CAD in Early Middle-Age with the Addition of PRS.

Figure 4.

In the UK Biobank (N=327,837), we show is the proportion of cumulative CAD events predicted using high genomic risk (PRS in the top quintile), intermediate to high clinical risk (PCE 10-year risk ≥7.5%) or both at enrollment, by age of estimation. B. Mean age of CAD event decreased with increasing PRS (red), from 67.2 (95% CI 66.6–67.8) years in the lowest decile to 64.5 (95% CI 64.1–65.0) years in the highest decile. Conversely, those in the highest PCE decile (blue) had events 13.7 years later in life than those of the lowest PCE. C. AUC of a model considering clinical risk only when compared to a combined clinical and genomic risk model for participants in 5-year age strata between ages 40 and 75 years at age of risk estimation. Genomic risk categories are defined as PRS in the top quintile, middle three quintiles, and bottom quintiles. Clinical risk categories are defined by PCE predicted 10-year risk <7.5%, 7.5–20%, and > 20%.

CAD: coronary artery disease, PRS: polygenic risk score, PCE: Pooled Cohort Equations. AUC: Area Under the Receiver Operator Curve