Table 1.
Characteristics of Study Participants from the FOS (N=3,588) and UKB (N=327,837)
| Characteristics | FOS (N=3,588) | UKB (N=327,837) |
|---|---|---|
| Age at risk estimation, mean (SD), years | 35.9 (10.2) | 56.1 (8.1) |
| Female, n (%) | 1,828 (50.9) | 186,507 (56.9) |
| White race, n (%) | 3,588 (100) | 274,927 (83.9) |
| Incident CAD, n (%) | 695 (19.3) | 11,190 (3.4) |
| Follow-up period, median [IQR) | 43.7 [38.7–45.3) | 12.1 [11.4–12.7) |
| Diabetes mellitus, n (%) | 27 (0.7) | 2413 (0.7) |
| Current smoking, n (%) | 1581 (44.1) | 33869 (10.3) |
| Total cholesterol, mean (SD), mg/dL | 197 (38.8) | 228.6 (41.4) |
| HDL Cholesterol, mean (SD), mg/dL | 52.1 (16.0) | 57.2 (14.8) |
| LDL cholesterol, mean (SD), mg/dL | 127 (36.6) | 144.0 (31.9) |
| Triglycerides, mean (SD), mg/dL | 99.1 (86.7) | 151.9 (90.3) |
| Diastolic blood pressure, mean (SD), mmHg | 78.5 (10.9) | 82.8 (11.2) |
| Systolic blood pressure, mean (SD), mmHg | 121 (16.4) | 139.7 (20.4) |
| Taking antihypertensive medication, n (%) | 102 (2.8) | 41,088 (12.5) |
| PCE 10-year risk category | ||
| Low or borderline (<7.5%), n (%) | - | 207,150 (63.2) |
| Intermediate (≥7.5 to <20%), n (%) | - | 96,775 (29.5) |
| High (≥20%), n (%) | - | 23,912 (7.3) |
| Genetic data available, n (%) | 2,656 (72.5) | 327,837 (100.0) |
| CAD polygenic risk score category | ||
| Low, n (%) | 531 (20.0) | 65,696 (20.0) |
| Intermediate, n (%) | 1,593 (60.0) | 196,750 (60.0) |
| High, n (%) | 532 (20.0) | 65,391 (20.0) |
Characteristics for study participants from the Framingham Offspring Study (FOS) and UK Biobank are reported for all individuals based on data obtained at enrollment. CAD: coronary artery disease, PRS: polygenic risk score, PCE: Pooled Cohort Equations, HDL: High-density lipoprotein cholesterol, LDL: Low-density lipoprotein cholesterol.