Table 3.
Top significant trait associations in the SLCO3A1 phenome-wide association analysis
| Trait | Domain | Reference | P-values | Participants (n) |
|---|---|---|---|---|
| Educational attainment | Environment | Okbayet al. (2016) | 9.28 × 10−8 | 328 917 |
| Broad depression | Psychiatric | Howard et al. (2018) | 6.06 × 10−7 | 322 580 |
| Educational attainment | Environment | Lee et al. (2018) | 8.40 × 10−7 | 766 345 |
| Seen doctor (GP) for nerves, anxiety, tension or depression | Psychiatric | Watanabe et al. (2019) | 2.42 × 10−6 | 383 771 |
| Alcohol dependence | Psychiatric | Wang et al. (2013) | 1.66 × 10−5 | 2322 |
| Lifetime number of sexual partners | Reproduction | Watanabe et al. (2019) | 4.52 × 10−5 | 316 569 |
| Depression | Psychiatric | Howard et al. (2019) | 1.13 × 10−4 | 500 199 |
A total of 436 GWAS were included in the PheWas., the Bonferroni corrected P-value threshold is 1.15 × 10−4.