TABLE 2.
Comparison of Daily Biological Parameters and Daily Heparin Dose on the Day of the Paired Activated Partial Thromboplastin Time/Anti-Factor-Xa Between Concordant/Discordant Paired Activated Partial Thromboplastin Time/Anti-Factor-Xa
| Variables | Concordant Pairs (Reference) (n = 379) | Discordant “Low” (n = 66) | Discordant “High” (n = 136) | p a | |
|---|---|---|---|---|---|
| Reference vs. “Low” | Reference vs. “High” | ||||
| Lowest hemoglobin (g/L) | 84 (77–92.5) | 84 (78–93.8) | 83.5 (75.8–99) | 0.61 | 0.39 |
| Highest hemoglobin (g/L) | 97 (90–106) | 94.5 (89–105) | 99.50 (92–114) | 0.72 | 0.71 |
| Highest plasma free hemoglobin (g/L) | 5 (3–8) | 4 (3–6) | 6 (4–11) | 0.43 | 0.21 |
| Lowest corrected ionized calcium (mmol/L) | 1.12 (1.04–1.22) | 1.14 (1.08–1.19) | 1.08 (1.02–1.19) | 0.34 | 0.63 |
| Highest urea (mmol/L) | 10 (8–13) | 10 (8.25–12) | 11 (7–16) | 0.45 | 0.30 |
| Highest bilirubin (µmol/L) | 12 (8–20) | 8 (5–16) | 12 (11–19.8) | 0.60 | 0.17 |
| Lowest arterial pH | 7.36 (7.31–7.42) | 7.34 (7.3–7.38) | 7.40 (7.33–7.44) | 0.12 | 0.08 |
| Highest d-dimer (mg/L) | 114 (34–184) | 146 (73–220) | 127 (56–155) | 0.18 | 0.91 |
| Highest INR | 1.2 (1.1–1.3) | 1.1 (1.1–1.2) | 1.1 (1–1.3) | 0.54 | < 0.001 |
| Lowest INR | 1.2 (1.1–1.3) | 1.2 (1–1.3) | 1.2 (1–1.3) | 0.69 | 0.35 |
| Highest fibrinogen (g/L) | 4.7 (3.5–6.3) | 5 (4.5–6.3) | 4.4 (2.3–6) | 0.19 | 0.26 |
| Lowest fibrinogen (g/L) | 4.8 (3.4–6.4) | 5.1 (4.2–6.2) | 4.7 (3.1–6) | 0.33 | 0.44 |
| Highest PT (s) | 15 (14.3–16.3) | 15.25 (14.4–16) | 14.5 (13.5–15.8) | 0.45 | < 0.001 |
| Lowest PT (s) | 15 (14–16.2) | 15.3 (14.1–16.4) | 14.8 (13.8–15.8) | 1 | 0.2 |
| Highest platelet count (G/L) | 168 (113–246) | 260 (128–330) | 139 (86–177) | 0.002 | < 0.001 |
| Lowest platelet count (G/L) | 174 (117–241) | 208.5 (111–255) | 140 (77–178) | 0.003 | < 0.001 |
| Daily heparin dose, U/24 hr | 20,400 (12,000–34,600) | 43,200 (24,963–52,800) | 13,600 (10,800–24,688) | 0.003 | 0.59 |
| Pairs in patients randomized in “the therapeutic anticoagulation group,” n (%) | 210 (55.4) | 43 (65.2) | 89 (65.4) | 0.07 | 0.06 |
INR = international normalized ratio, PT = prothrombin time.
a
p value was obtained with Satterthwaite approximation method derived from a linear mixed model analysis to account for repeated measures.
Discordant was considered as “low” when activated partial thromboplastin time (aPTT) was relatively lower than anti-factor-Xa (anti-Xa) and “high” when aPTT was relatively higher than anti-Xa. All variables are expressed as median (interquartile range).