Table 1.

Model parameters, units and PSO bounds

Parameter	Description	Units	Lower bound	Upper bound
B50	Antigen toggle switch half-maximum	Number of antigen molecules	106	1010
μB	B cell proliferation rate	1/day	0.001	0.1
kkill	Rate of B cell killing by T effectors	1/day	0.001	1
floss	Fraction of dose lost	1/day	1	1000
TK50	B cell killing half-maximum	Cells	105	109
kt	B cell killing Hill exponent	Dimensionless	0.2	3
kB1	Antigen generation rate	Number of antigen/(day×cell)	0.001	1
kB2	Antigen clearance rate	1/day	0.001	1
μM	T memory proliferation rate	1/day	0.001	1
km	T memory self-renewal Hill exponent	Dimensionless	0.2	3
fmax	T memory maximum fraction of self-renewal	Dimensionless	0.5	0.99
ke	T effector proliferation Hill exponent	Dimensionless	0.2	3
μE	T effector proliferation rate	1/day	0.001	1
N	Number of population doublings in TE2	Dimensionless	4	12
kex	T effector exhaustion rate	1/day	0.001	1
dM	T memory death rate	1/day	0.001	1
dE1	T effector (TE1) death rate	1/day	0.001	1
dE2	T effector (TE2) death rate	1/day	0.001	1
dX	T exhausted death rate	1/day	0.001	1
Bmax	B cell tumor carrying capacity	Cells	108	1012
kx	T exhaustion Hill exponent	Dimensionless	0.2	3
kr	T memory regeneration Hill exponent	Dimensionless	0.2	3
rM	T memory regeneration from T effectors	1/day	0.001	1
fractionTM	T memory fraction of dose	1/day	1	10
fractionTE1	T effector (TE1) fraction of dose	1/day	1	10
fractionTE2	T effector (TE2) fraction of dose	1/day	30	70
fractionTX	T exhausted fraction of dose	1/day	5	30