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. 2023 Feb 23;41(11):1633–1644. doi: 10.1038/s41587-023-01688-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, Relative abundances (box plots and top-part y axis) and prevalences (bar plots and bottom-part y axis) of the uncharacterized species (uSGB) Lachnospiraceae SGB4894 are substantially higher in healthy individuals (n = 738 samples) in comparison with patients suffering from several gastrointestinal related diseases (n = 1,183 samples), and this difference is reproducible across populations (one-sided Mann–Whitney U test). Box plots show the median (center), 25th/75th percentile (lower/upper hinges), 1.5× interquartile range (whiskers) and outliers (points). b, Lachnospiraceae SGB4894 shows within-species genetic diversity strongly linked to geographic origin and lifestyle. c, Pairwise geographic distances between strains of different countries correlate with their median genetic distances (Spearman’s ρ = 0.505; see Methods), suggesting that human Lachnospiraceae SGB4894 strains could have followed an isolation-by-distance pattern.