Figure 1.

Line graph showing norepinephrine-equivalent doses at vasopressin initiation, modeled as a restricted cubic spline with three knots (placed by the algorithm at 10 μg/min, 25 μg/min, and 60 μg/min), were used to create a prediction model for in-hospital mortality, adjusting for severity and known confounders. The shaded red area indicates the 95% CI of the predicted probability. Initiation of vasopressin at lower norepinephrine-equivalent doses was associated with lower odds of in-hospital mortality. Initiation at 10 μg/min vs 25 μg/min: OR, 0.75 (95% CI, 0.65-0.88); initiation at 10 μg/min vs 60 μg/min: OR, 0.39 (95% CI, 0.24-0.65); and initiation at 25 μg/min vs 60 μg/min: OR, 0.52 (95% CI, 0.36-0.74). (Reprinted with permission from Sacha et al.⁵¹)