Table 3.
Total LTPA (Baseline to 3 Months) Related to Cardiovascular Health Measures in BC Participants
| Exercise Capacity, m | LV End-Diastolic Volume, mL | LV End-Systolic Volume, mL | |
|---|---|---|---|
| 3-mo visit | −9.1 ± 3.5(−16 to −2.2) | 2.2 ± 0.8(0.5 to 3.8) | 2.6 ± 0.5(1.7 to 3.6) |
| Stage III BC | 14.3 ± 10.1 (−5.6 to 34.2) | 5.7 ± 2.9 (−0.1 to 11.4) | 2.0 ± 1.7 (−1.3 to 5.3) |
| Stage II BC | −8.8 ± 7.0 (−22.7 to 5.0) | −6.1 ± 2(−10 to −2.1) | −2.4 ± 1.2(−4.6 to -0.1) |
| 3-mo visit ∗ stage III BC | −5.5 ± 6.0 (−17.3 to 6.4) | 3.6 ± 1.4(0.8 to 6.4) | 2.6 ± 0.8(1.0 to 4.3) |
| 3-mo visit ∗ stage II BC | −7.3 ± 4.1 (−15.4 to 0.8) | −3.1 ± 1(−5.0 to −1.1) | −1.0 ± 0.6 (−2.1 to 0.2) |
| Age, y | −2.3 ± 0.4(−3.2 to −1.5) | −0.7 ± 0.1(−0.9 to −0.4) | −0.4 ± 0.1(−0.6 to -0.3) |
| Body mass index, kg/m2 | −3.9 ± 0.7(−5.3 to −2.4) | 1.3 ± 0.2(0.9 to 1.7) | 0.4 ± 0.1(0.2 to 0.7) |
| Total LTPAa | 7.1 ± 1.6(4.0 to 10.1) | 1.2 ± 0.4(0.4 to 2.0) | 0.3 ± 0.2 (−0.2 to 0.7) |
| Total LTPAa ∗ 3-mo visit | — | — | — |
| Anthracycline | −0.02 ± 5.1 (−10.0 to 10.0) | −1.3 ± 1.5 (−4.1 to 1.6) | −0.7 ± 0.8 (−2.4 to 0.9) |
| Anthracycline ∗ 3-mo visit | — | — | — |
| LV Ejection Fraction, % | LV Circumferential Strain, % | |
|---|---|---|
| 3-mo visit | −1.4 ± 0.3(−2.0 to −0.8) | 1.2 ± 0.2(0.8 to 1.6) |
| Stage III BC | 0.4 ± 0.8 (−1.2 to 2.0) | −0.39 ± 0.49 (−1.36 to 0.58) |
| Stage II BC | −0.2 ± 0.6 (−1.3 to 0.9) | 0.32 ± 0.35 (−0.36 to 1.0) |
| 3-mo visit ∗ Stage III BC | −1.0 ± 0.5 (−2.0 to 0.1) | 0.57 ± 0.35 (−0.12 to 1.25) |
| 3-mo visit ∗ Stage II BC | −0.3 ± 0.4 (−1.0 to 0.4) | 0.003 ± 0.24 (−0.48 to 0.48) |
| Age, y | 0.1 ± 0.04(0.1 to 0.2) | −0.07 ± 0.02(−0.11 to −0.03) |
| Body mass index, kg/m2 | 0.1 ± 0.1 (−0.1 to 0.2) | 0.05 ± 0.04 (−0.02 to 0.12) |
| Total LTPAa | 0.2 ± 0.1 (−0.1 to 0.4) | 0.05 ± 0.08 (−0.12 to 0.21) |
| Total LTPAa ∗ 3-mo visit | — | −0.16 ± 0.07(−0.29 to −0.02) |
| Anthracycline | 0.2 ± 0.4 (−0.6 to 1.0) | 0.44 ± 0.25 (−0.05 to 0.92) |
| Anthracycline ∗ 3-mo visit | — | −0.62 ± 0.17(−0.96 to −0.28) |
Values are beta ± SE (95% CI). All models include a patient level random effect. Bold values indicate statistically significant (P < 0.05) findings regarding leisure-time physical activity (LTPA).
— = not statistically significant and removed from the model; BC = breast cancer; LV = left ventricular.
a
Square root transformed. Visit variable compares 3-month visit to baseline visit. Anthracycline variable compares no treatment to receiving treatment.