Table 2.

Potential Therapeutic Effects of Exercise Within Each Level of Prevention

	Vo2peak	Cardiac Function	Cardiac Injury Biomarkers
Primary prevention	Possible prevention of substantial treatment-induced declines if exercise volume is sufficient	Possible prevention of substantial treatment-induced detrimental changes in LVEF, GLS, cardiac output, and stroke volume	Possible prevention of substantial treatment-induced detrimental changes
Secondary prevention	Improvement, but how much improvement may be influenced by cancer diagnosis and time out from treatment	Possible improvement of some measures of cardiac function (eg, resting heart rate)	Unknown
Tertiary prevention	Possible improvement	Unknown	Unknown

GLS = global longitudinal strain; LVEF = left ventricular ejection fraction; Vo_2peak = maximal oxygen consumption.