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. 2023 Nov 8;31(11):1804–1819.e9. doi: 10.1016/j.chom.2023.09.013

Figure 5.

Figure 5

Functional characterization of the human ScC species

(A) PCoA based on the Jaccard distances of the UniRef50 families (PERMANOVA p < 0.001).

(B) Prevalence (%) of selected UniRef50 families (except carbohydrate-metabolism-related families) depleted and enriched in the ScC species. All UniRef50 families shown were significantly enriched/depleted in one species compared with all other species separately (as defined by coupled Fisher’s exact tests between each pair of species, false discovery rate [FDR] < 0.01).

(C) Prediction of total carbohydrate-active enzymes (CAZymes) in the different ScC species. (Kruskal-Wallis p = 1.7287e−68.).

(D) Prediction of total PULs in the different ScC species (Kruskal-Wallis p = 2.5194e−70).

(E) PCoA based on the Jaccard distances of the predicted CAZymes between S. brunsvicensis (clade B) MAGs reconstructed from Westernized or non-Westernized individuals (PERMANOVA p = 0.0099).

(F) PCoA based on the Jaccard distances of the predicted PULs between S. brunsvicensis (clade B) MAGs reconstructed from Westernized or non-Westernized individuals (PERMANOVA p = 0.0199). Boxplots in (C) and (D) show the median (center), 25th/75th percentile (lower/upper hinges), 1.5× interquartile range (whiskers) and outliers (points). See also Figures S10 and S11 and Table S2.