Table 3.
Laboratory findings from the study groups
| Laboratory findings | MAS, N = 39 | Non-MAS, N = 375 | p value |
|---|---|---|---|
| ESR, mm/h; mean ± SD | 75.5 ± 29.4 | 79.5 ± 32.4 | 0.43 |
| CRP mg/dl; median (IQR) | 16 (20.5) | 13.35 (23.175) | 0.21 |
| Anemia, N (%) | 23 (58.9) | 204 (54.4) | 0.69 |
| Leukocytosis, N (%) | 29 (74.4) | 255 (68) | 0.58 |
| White blood cell count, cells/mmc; median (IQR) | 18,000 (4150) | 16,955 (5400) | 0.15 |
| Absolute neutrophil count, cells/mmc; median (IQR) | 15,662 (5320) | 14,434.5 (5782) | 0.06 |
| Thrombocytosis, N (%) | 3 (9.4) | 83 (22.1) | 0.04 |
| Normal platelet count, N (%) | 20 (51.3) | 270 (72) | 0.03 |
| Thrombocytopenia, N (%) | 16 (41) | 22 (5.9) | < 0.001 |
| Abnormal liver function, N (%) | 26 (66.7) | 153 (40.8) | 0.009 |
| Increased AST, N (%) | 25 (64.1) | 119 (31.7) | 0.002 |
| Increased ALT, N (%) | 22 (56.4) | 120 (32) | 0.04 |
| Conjugated hyperbilirubinemia, N (%) | 5 (12.8) | 6 (1.6) | 0.004 |
| Total hyperbilirubinemia, N (%) | 4 (10.3) | 6 (1.6) | 0.049 |
| Hypoalbuminemia, N (%) | 21 (53.8) | 90 (24) | 0.002 |
| Increased ferritin, N (%) | 36 (92.3) | 318 (84.8) | 0.18 |
| Ferritin, ng/ml; median (IQR) | 6908 (30,106.5) | 1559.5 (5355) | 0.003 |
| Increased LDH, N (%) | 29 (74.4) | 146 (38.9) | 0.001 |
| LDH (U/L, mean ± SD) | 790 (1906.5) | 487 (219) | < 0.001 |
| Hypergammaglobulinemia, N (%) | 8 (20.5) | 63 (16.8) | 0.99 |
| Increased β2-microglobulin, N (%) | 5 (12.8) | 80 (21.3) | 0.65 |
p values were obtained with Student’s t test or Mann–Whitney U test (according to data distribution) for quantitative data and Chi-square test for qualitative data
ALT alanine aminotransferase, AST aspartate aminotransferase, CRP C-reactive protein, ESR erythrocyte sedimentation rate, IQR interquartile range, LDH lactate dehydrogenase, MAS macrophage activation syndrome, SD standard deviation