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. 2023 Sep 23;50(11):9521–9527. doi: 10.1007/s11033-023-08695-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — miRNA biogenesis and mechanism of action. The process begins with transcription in the cell nucleus, the Drosha enzyme cleaves the pri-miRNA to produce the precursor-miRNA (pre-miRNA), which is transported thanks to exportin 5 to the cytoplasm, where it binds with the cell nucleus. DICER protein to complete its maturation and forms a complex with the RISC protein whose objective is to inhibit gene translation