Table 1.
Clinicopathological parameters of stage II–III colon carcinoma patients (n = 869).
| Clinicopathological parameters | Total no | TLR1-N248 | p value | TLR1-S602 | p value | TLR2-N729S | p value | TLR2 promoter (− 196 to − 174) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | Variant | WT | Variant | WT | Variant | WT | Variant | ||||||
| 869 | 144 | 725 | 853 | 16 | 867 | 2 | 373 | 494 | |||||
| Gender | 0.516 | 0.846 | 1 | 0.416 | |||||||||
| Female | 401 | 70 | 331 | 394 | 7 | 400 | 1 | 178 | 222 | ||||
| Male | 468 | 74 | 394 | 459 | 9 | 467 | 1 | 195 | 272 | ||||
| Age | 0.075 | 0.277 | 0.199 | 0.369 | |||||||||
| < 65 | 388 | 74 | 314 | 383 | 5 | 386 | 2 | 173 | 214 | ||||
| ≥ 65 | 481 | 70 | 411 | 470 | 11 | 481 | 0 | 200 | 280 | ||||
| Tumor location | 0.272 | 0.127 | 1 | 0.421 | |||||||||
| Proximal colon | 398 | 59 | 339 | 394 | 4 | 397 | 1 | 165 | 233 | ||||
| Distant colon | 466 | 82 | 384 | 454 | 12 | 465 | 1 | 205 | 259 | ||||
| Unspecified | 5 | 3 | 2 | 5 | 0 | 5 | 0 | 3 | 2 | ||||
| pT stage | 0.821 | 1 | 1 | 0.134 | |||||||||
| pT1-2 | 33 | 5 | 28 | 33 | 0 | 33 | 0 | 10 | 23 | ||||
| pT3-4 | 835 | 139 | 696 | 819 | 16 | 833 | 2 | 362 | 471 | ||||
| pN stage | 0.278 | 0.198 | 1 | 0.579 | |||||||||
| Negative | 459 | 82 | 377 | 448 | 11 | 458 | 1 | 193 | 265 | ||||
| Positive | 410 | 62 | 348 | 405 | 5 | 409 | 1 | 180 | 229 | ||||
| TNM stage (7th AJCC) | 0.278 | 0.198 | 1 | 0.579 | |||||||||
| Stage II | 459 | 82 | 377 | 448 | 11 | 458 | 1 | 193 | 265 | ||||
| Stage III | 410 | 62 | 348 | 405 | 5 | 409 | 1 | 180 | 229 | ||||
| Tumor differentiation | 1.00 | 1.00 | 1.00 | 0.25 | |||||||||
| Well to moderate | 850 | 140 | 710 | 835 | 15 | 848 | 2 | 365 | 483 | ||||
| Poor | 7 | 1 | 6 | 7 | 0 | 7 | 0 | 1 | 6 | ||||
| Unknown | 12 | 3 | 9 | 11 | 1 | 12 | 0 | 7 | 5 | ||||
| MMR status | 0.865 | 1.00 | 1.00 | 0.312 | |||||||||
| pMMR | 796 | 131 | 665 | 781 | 15 | 794 | 2 | 339 | 455 | ||||
| dMMR | 69 | 12 | 57 | 68 | 1 | 69 | 0 | 34 | 35 | ||||
| Unknown | 4 | 1 | 3 | 4 | 0 | 4 | 0 | 0 | 4 | ||||
| Lymphovascular invasion | 0.998 | 0.153 | 1 | 0.85 | |||||||||
| Absent | 423 | 70 | 353 | 418 | 5 | 422 | 1 | 183 | 239 | ||||
| Present | 441 | 73 | 368 | 430 | 11 | 440 | 1 | 188 | 252 | ||||
| Unknown | 5 | 1 | 4 | 5 | 0 | 5 | 0 | 2 | 3 | ||||
| Perineural invasion | 0.532 | 0.621 | 0.529 | 0.093 | |||||||||
| Absent | 535 | 85 | 451 | 527 | 9 | 534 | 2 | 242 | 293 | ||||
| Present | 326 | 57 | 269 | 319 | 7 | 326 | 0 | 128 | 197 | ||||
| Unknown | 8 | 2 | 6 | 8 | 0 | 8 | 0 | 4 | 4 | ||||
| Local recurrence | 0.734 | 0.619 | 1 | 0.116 | |||||||||
| Absent | 809 | 135 | 674 | 793 | 16 | 807 | 2 | 353 | 454 | ||||
| Present | 60 | 9 | 51 | 60 | 0 | 60 | 0 | 20 | 40 | ||||
| Distant metastasis | 0.93 | 1 | 0.31 | 0.748 | |||||||||
| Absent | 722 | 140 | 602 | 708 | 14 | 721 | 1 | 308 | 412 | ||||
| Present | 147 | 24 | 123 | 145 | 2 | 146 | 1 | 65 | 82 | ||||
| Adjuvant chemotherapy | 0.553 | 0.435 | 0.14 | 0.996 | |||||||||
| Yes | 325 | 57 | 268 | 321 | 4 | 323 | 2 | 139 | 184 | ||||
| No | 544 | 87 | 457 | 532 | 12 | 544 | 0 | 234 | 310 | ||||
Pearson test was used, and Fisher’s exact test was used when counts were less than 5. The test did not include the “unknown or unspecified” group.