Table 3.
Univariate and multivariate analysis of DMFS and known prognostic factors in stage III colon carcinoma patients.
| Parameters | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Sex (Male vs. Female) | 0.99 | 0.743–1.320 | 0.946 | |||
| Age (≥ 65 vs. < 65) | 1.86 | 1.377–2.510 | < 0.001 | 1.826 | 1.35–2.469 | < 0.001 |
| pT stage (pT3-4 vs. pT1-2) | 5.278 | 1.959–14.220 | 0.001 | 4.489 | 1.653–12.190 | 0.003 |
| Tumor location (Proximal vs. Distal) | 0.753 | 0.565–1.005 | 0.054 | |||
| Tumor differentiation (Poor vs. Well to moderate) | 1.523 | 0.213–10.879 | 0.675 | |||
| Lymphovascular invasion (Present vs. Absent) | 1.428 | 1.014–2.009 | 0.041 | 1.26 | 0.889–1.784 | 0.194 |
| Perineural invasion (Present vs. Absent) | 1.476 | 1.103–1.974 | 0.009 | 1.224 | 0.909–16.49 | 0.183 |
| TLR1-N248 (Variant vs. WT) | 1.725 | 1.084–2.745 | 0.021 | 1.694 | 1.063–2.698 | 0.027 |
| TLR2 promoter (Variant vs. WT) | 1.052 | 0.787–1.406 | 0.734 | |||