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. 2023 Nov 9;13:19436. doi: 10.1038/s41598-023-46607-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Boxplot representation of the three nuclear categories (small-sized, intermediate-sized, and large-sized) as classified independently by three pathologists. For each sample image, the three pathologists selected and measured 20 nuclei relevant to their classification decision. The boxplots indicate the diameter of these nuclei (totaling 60 per image) relative to our new reference.