TABLE 1.
Summary of the genome-wide interaction loci (P < 5×10-8) of folic acid supplement intake (yes/no) on colorectal cancer (CRC) risk from the common variant analyses
| rsID | Chr | Position | Band | A1 | A2 | Primary GxE testing |
Secondary GxE testing |
||
|---|---|---|---|---|---|---|---|---|---|
| PGxE | P3DF | PG|E, case-only | P2DF | ||||||
| rs150924902 | 3 | 12041456 | p25.2 | T | A | 1.44×10-8 | 1.76×10-7 | 3.36×10-5 | 5.21×10-8 |
| rs1291413 | 6 | 23445253 | p22.3 | T | A | 7.98×10-4 | 1.80×10-5 | 4.94×10-8 | 3.49×10-3 |
A1, effect allele; A2, reference allele; Band, chromosomal band; Chr, chromosome; PGxE, P value of interaction component for CRC risk (H0: βGxE=0); P3DF, P value of 3DF test (H0: βGxE=βD|G=δG=0); PG|E, case-only, P value of genetic component for the exposure among cases (H0: δG=0); P2DF, P value of 2-degree of freedom (DF) test (H0: βGxE=βD|G=0); Position, base pair position; rsID, single nucleotide polymorphism rs number.