TABLE 2.
Odds ratios for colorectal cancer stratified by interaction loci genotypes and folic acid supplement use
| chr3:12041456, rs150924902, 3p25.2 |
chr6:23445253, rs1291413, 6p22.3 |
|||||
|---|---|---|---|---|---|---|
| TT | TA | AA | TT | TA | AA | |
| Folic acid supplement=No | reference | 0.82 (0.70, 0.95) | 0.02 (0, 100) | reference | 1.02 (0.97, 1.08) | 1.08 (1.02, 1.15) |
| P = 0.010 | P = 0.35 | P = 0.38 | P = 0.015 | |||
| Folic acid supplement=Yes | 0.82 (0.79-0.86) | 1.33 (1.11, 1.58) | 0.36 (0.04, 3.33) | 0.91 (0.85, 0.97) | 0.84 (0.79, 0.89) | 0.83 (0.77, 0.90) |
| P = 9.1×10-21 | P = 0.002 | P = 0.37 | P = 0.004 | P = 1.5×10-8 | P = 4.6×10-6 | |
| E param by G: | ||||||
| Folic acid supplement (yes vs. no) | 0.82 (0.79, 0.86) | 1.63 (1.29, 2.05) | 24.03 (0, 208,977) | 0.91 (0.85, 0.97) | 0.82 (0.78, 0.87) | 0.77 (0.70, 0.83) |
| P = 9.1×10-21 | P = 4×10-5 | P = 0.49 | P = 0.004 | P = 2.1×10-12 | P = 8.7×10-10 | |
| G param by E: | ||||||
| Folic acid supplement=No | reference | 0.82 (0.70, 0.95) | 0.02 (0, 100.02) | reference | 1.02 (0.97, 1.08) | 1.08 (1.02, 1.15) |
| P = 0.010 | P = 1.2×10-7 | P = 0.38 | P = 0.017 | |||
| Folic acid supplement=Yes | reference | 1.61 (1.35, 1.93) | 0.44 (0.05, 4.05) | reference | 0.93 (0.87, 0.99) | 0.91 (0.84, 0.99) |
| P = 0.35 | P = 0.47 | P = 0.015 | P = 0.032 | |||
| Counts (Ca/Co): | ||||||
| Folic acid supplement=No | 14,692/20,921 | 305/582 | 0/3 | 4494/6737 | 7377/10,583 | 3126/4186 |
| Folic acid supplement=Yes | 8716/13315 | 288/317 | 1/3 | 3064/4405 | 4343/6743 | 1597/2486 |
Estimates represent odds ratios and 95% confidence intervals adjusted for age at baseline, sex, study, genotyping platform, and the first 3 principal components. Number of case/control counts were calculated by imputed genotype probabilities. Ca, cases; Co, controls; E, exposure (folic acid supplement); G, genotype; param, parameterized.