Table 1.
Breakthrough infections in previously vaccinated or infected hamsters
| Self-amplifying RNA vaccinated | Direct contact exposed to virus | Infection confirmed by plaque assay | AUC (n = 4), (evaluated by plaque assay) | |
|---|---|---|---|---|
| saRNA-Spike | Delta | 4/4 (100%) | 15.5 | Median of (16.5, 12.4, 15.1, 15.9) |
| saRNA-HIV | Delta | 4/4 (100%) | 27.8 | Median of (28.6, 28.5, 24.1, 27.2) |
| saRNA-Spike | Omicron BA.1 | 4/4 (100%) | 14.3 | Median of (19.8, 14.9, 12.9, 13.7) |
| saRNA-HIV | Omicron BA.1 | 4/4 (100%) | 21.8 | Median of (27.0, 27.1, 16.7, 14.7) |
| Naïve or previously-infected | ||||
| Naive | Omicron BA.1 | 4/4 (100%) | 22.7 | Median of (22.2, 23.1, 24.1, 21.2) |
| WT/D614G | Omicron BA.1 | 1/4 (25%) | 5.8 | Single value |
| Alpha | Omicron BA.1 | 1/4 (25%) | 5.9 | Single value |
| Delta | Omicron BA.1 | 4/4 (100%) | 6.6 | Median of (3.0, 11.2, 2.0, 10.3) |
| Omicron BA.1 | Delta | 4/4 (100%) | 16.20 | Median of (14.9, 14.8, 17.6, 18.7) |
| Naive | Omicron BA.2 | 3/4 (75%) | 17.6 | Median of (8.0, 17.6, 18.8) |
| Omicron BA.1 | Omicron BA.2 | 1/4 (25%) | 1.0 | Single value |
| Naive | Omicron BA.4 | 4/4 (100%) | 16.7 | Median of (18.1, 18.7, 9.5, 15.2) |
| Omicron BA.1 | Omicron BA.4 | 4/4 (100%) | 5.0 | Median of (5.2, 4.9, 3.7, 6.2) |
| Naive | Omicron BA.5 | 4/4 (100%) | 21.1 | Median of (23.3, 20.2, 19.5, 22.0) |
| Omicron BA.1 | Omicron BA.5 | 4/4 (100%) | 7.5 | Median of (8.6, 6.5, 6.4, 14.3) |