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. 2023 Oct 31;120(45):e2306476120. doi: 10.1073/pnas.2306476120

Fig. 1.

Fig. 1.

IL-38 is essential for intestinal crypt gene expression. (A) Staining of IL-38 (green) and LGR5 (red) in wild-type SI. An enlargement of one intestinal crypt is shown in dashed frame. (Scale bar, 50 μm.) (B) gene expression of Il1f10 in skin and intestine of wild type mice. (C–V) gene expression analysis of Lgr5 (C), Fzd5 (D), Ephb2 (E), Bmpr1a (F), Pdgfa (G), Sox4 (H), Sox9 (I), Id4 (J), Smoc2 (K), Socs3 (L), Ascl2 (M), Cdk6 (N), Msi1 (O), Rgmb (P), Cdca7 (Q), Clca4 (R), Olfm4 (S), Phlda (T), Pla2g4a (U), and Lyz1 (V) in SIs of wild-type and Il1f10-deficient mice. Comparisons between WT and Il1f10 knockout samples were performed using Student t test. *P < 0.05; **P < 0.01, ***P < 0.001, ns = not significant. Mean ± SEM.