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. 2023 Oct 19;15(10):5534–5548. doi: 10.21037/jtd-23-125

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2023 Journal of Thoracic Disease. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Flow chart. (A) Design of the study. From the establishment of a clinical cohort to the collection, treatment and analysis of serum and then to the follow-up of those patients upon PC treatment. (B) Scheme to screen specific diagnostic biomarkers for PC. PC, patients with pulmonary cryptococcosis; UHPLC-MS, ultra high performance liquid chromatography-mass spectrometry technology; MRM, multiple reaction monitoring; OPLS-DA, orthogonal partial least squares discriminate analysis; VIP, variable importance in the projection; AUC, area under curve; PA, patients with pulmonary aspergillosis; TB, patients with pulmonary tuberculosis; SPL, sphingolipid.