Table 1. Evidence summary of cough in chronic respiratory disease.
Cough characteristics | Asthma | COPD | Bronchiectasis | ILD | Sarcoidosis |
---|---|---|---|---|---|
Prevalence of cough | 8–58% | 10–74% | 82–98% | 50–89% | 3–64% |
Impact of cough | ↑ GINA severity | ↑ SGRQ/CAT | ↑ BSI | ↑ Mortality† | ↓ FVC# |
↑ ACQ | ↓ FEV1 | ↑ CT severity | ↑ CT severity | ↓ ACE# | |
↓ FEV1 | ↑ Exacerbations# | ↑ Exacerbations | ↓ FVC | ↑ Dyspnoea | |
↑ Exacerbations | ↑ Dyspnoea | ↑ Sputum burden | ↓ DLCO | ||
↑ Dyspnoea | ↑ Dyspnoea | ||||
Impaired QoL, LCQ range | 13–18 | 13–19 | 12–16 | 15–17 | 15–17 |
Cough reflex sensitivity | ↑ | ↑ | ↑ | ↑ | ↑ |
↑, increased; ↓, decreased; †, data conflicting. COPD, chronic obstructive pulmonary disease; ILD, interstitial lung disease; GINA, Global Initiative for Asthma; SGRQ, St George’s Respiratory Questionnaire; CAT, COPD Assessment Tool; BSI, Bronchiectasis Severity Index; FVC, forced vital capacity; ACQ, Asthma Control Questionnaire; FEV1, forced expiratory volume in 1 second; CT, computed tomography; ACE, angiotensin converting enzyme; DLCO, diffusing capacity of the lungs for carbon monoxide; QoL, Quality of Life; LCQ, Leicester Cough Questionnaire (range, 3–21, lower score indicates worse cough-specific health status).