Table 1.

Targets of c-di-AMP in B. subtilis.

Target	Nature of the target	Function	Effect of c-di-AMP binding	Reference(s)
Targets related to potassium homeostasis
KimA	Protein	Potassium uptake	Inhibition of activity	Gundlach et al. 2019
c-di-AMP riboswitch (kimA)	RNA	Control of kimA expression	Transcription termination	Nelson et al. 2013
KtrA	Protein	Potassium uptake	Inhibition of activity	Gundlach et al. (2019)
c-di-AMP riboswitch (ktrAB)	RNA	Control of ktrAB expression	Transcription termination	Nelson et al. (2013)
KtrC	Protein	Potassium uptake	Inhibition of activity	Gundlach et al. (2019)
CpaA	Protein	Potassium export	Stimulation of activity	Gundlach et al. (2019)
KhtT	Protein	Potassium export	Stimulation of activity	Gundlach et al. (2019)
Other targets
OpuCA	Protein	Uptake of compatible solutes	Inhibition of activity	Gundlach et al. (2019)
MgtE	Protein	Magnesium uptake	?	Gundlach et al. (2019)
Third messenger targets
DarA	Protein	Signal transduction	Not known	Gundlach et al. (2015b)
DarB	Protein	Signal transduction, control of Rel and PycA activities	No interaction with Rel and PycA	Gundlach et al. (2019)