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. 2023 Oct 24;5(6):fcad289. doi: 10.1093/braincomms/fcad289

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Published by Oxford University Press on behalf of the Guarantors of Brain 2023.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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A high-rate leader (hiRL)-dominated spike network that could support seizures. (A) A schematic illustrating a hypothesized spike network in seizure-free patients. In the seizure onset zone (SOZ, area shaded light red), there are many hiRL (circles with yellow halo) and in non-SOZ (NSOZ, area shaded blue), a single hiRL is represented. Regions that lead or are downstream in spike sequences are denoted by orange- and green-filled circles. The number of regions that generate or propagate spikes and the number of hiRL affects the efficiency of the network. The path between regions 1 and 2 (arrows highlighted in red) is disrupted if the SOZ is removed or treated. (B) Same as A but for not seizure-free patients. There are many hiRL that can lead or are downstream in spike sequences. Unlike the single path between regions 1 and 2 in seizure-free patient in panel A, there are multiple paths for spike propagation between regions 1 and 2 in not seizure-free patients, and removal of the SOZ only disrupts one path, while alternative paths remain for spike propagation (arrows highlighted in green).