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. 2004 Jan 26;2004(1):CD003918. doi: 10.1002/14651858.CD003918.pub2

Piver 1974.

Methods Randomized, double blind, placebo controlled
Participants n=41 FIGO stage IIB or IIIB ca cx
Interventions RT ‐ 40 ‐ 50Gy EBRT in 2Gy fractions followed by ICR & VR. Point A dose = 85Gy.
 HU ‐ 80mg/kg 3 x wk over 12 wks
Outcomes Acute chemotherapy toxicity
 NED rate
Notes Trial stopped as high proportion of 3b pts had PA node mets
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Low risk A ‐ Adequate