Piver 1989.
Methods | Randomized, placebo controlled | |
Participants | n=27, FIGO stage IIIB who refused or were not fit for PAL | |
Interventions | RT ‐ planned ‐ 60Gy EBRT in 6wks, but 9 received split course, 5 in HU group and 4 in placebo group. EBRT followed by ICR to give point A further 25Gy. HU ‐ 80mg/kg 3d per wk for 12 wks. | |
Outcomes | Acute chemotherapy toxicity Recurrence rate DFS | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ Adequate |
RT ‐ radiotherapy ICR ‐ intra‐cavitary radium VR ‐ vaginal radium HU ‐ hydroxyurea ca cx ‐ carcinoma cervix Min TD ‐ minimum tumour dose EBRT ‐ external beam radiotherapy PAL ‐ paraaortic lymphadenectomy FU ‐ follow up y ‐ year(s) d ‐ day(s) wk ‐ week(s) pts ‐ patients mets ‐ metastases NED ‐ no evidence of disease DFS ‐ disease free survival PFI ‐ progression‐free interval