Piver 1989.

Methods	Randomized, placebo controlled
Participants	n=27, FIGO stage IIIB who refused or were not fit for PAL
Interventions	RT ‐ planned ‐ 60Gy EBRT in 6wks, but 9 received split course, 5 in HU group and 4 in placebo group. EBRT followed by ICR to give point A further 25Gy. HU ‐ 80mg/kg 3d per wk for 12 wks.
Outcomes	Acute chemotherapy toxicity Recurrence rate DFS
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Low risk	A ‐ Adequate

RT ‐ radiotherapy
 ICR ‐ intra‐cavitary radium
 VR ‐ vaginal radium
 HU ‐ hydroxyurea
 ca cx ‐ carcinoma cervix
 Min TD ‐ minimum tumour dose
 EBRT ‐ external beam radiotherapy
 PAL ‐ paraaortic lymphadenectomy
 FU ‐ follow up
 y ‐ year(s)
 d ‐ day(s)
 wk ‐ week(s)
 pts ‐ patients
 mets ‐ metastases
 NED ‐ no evidence of disease
 DFS ‐ disease free survival
 PFI ‐ progression‐free interval