Figure 6.

Characterization of genes regulated by Sox11 and Silc1 by RNA-seq

(A) Top: heatmap of changes in gene expression relative to the respective controls of the 33 genes that were upregulated following AAV-mediated Sox11 OE in the hippocampus and downregulated following AAV-mediated introduction of Cre into the hippocampus of Sox11^fl/fl mice (p < 0.05, fold change of at least 50%). Bottom: boxplots of the same changes, with p values computed using a two-sided one-sample t test.

(B) Immunostaining with anti-Draxin (red) and DAPI (blue) in the hippocampi of WT and Silc1^−/− mice under HC and NE conditions (Sox11 OE and Cre- or control-injected Sox11^fl/fl mice). Imaging was performed using a 20× objective (scale bar, 200 μm).

See also Figures S5 and S6 and Table S1.