REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-SOX11	Merck Millipore	Cat#ABN105
Mouse anti-NeuN	Merck Millipore	Cat#MAB377; RRID: AB_2298772
Rabbit anti-Draxin	Abcam	Cat#ab117452; RRID: AB_10898861
Mouse anti-Beta-tubulin	Sigma	Cat#T4026; RRID: AB_477577
AzureSpectra 700 Goat-anti-mouse secondary antibody	Azure biosystem	Cat#AC2129
AzureSpectra 800 Goat-anti-rabbit secondary antibody	Azure biosystem	Cat#AC2134
Donkey anti-Mouse Alexa 594	Molecular Probes	Cat#A21203; RRID: AB_141633
Goat anti Rabbit Alexa 647	Abcam	Cat#ab150079; RRID: AB_2722623
Bacterial and virus strains
AAV9 pENN.AAV.CamkII.HI.GFP-Cre.WPRE.SV40	Addgene	105551-AAV9
AAV-9 pENN.AAV.CamKII0.4.eGFP.WPRE.rBG	Addgene	105541-AAV9
AAV-9 Silc1	This study	N/A
AAV-9 Sox11	This study	N/A
Chemicals, peptides, and recombinant proteins
Papain	Sigma	P4762
Dispase II	Roche	165859
Percoll	Sigma	P1644
Poly L lysin	Sigma	P4832
Laminin	Life	23017–015
Collagenase type II	Worthington	CSL-2
Critical commercial assays
SENSE mRNA-Seq Library Prep Kit V2	Lexogen	001.96
ACD RNAscope Fluorescent Multiplex Assay	ACDBio	320850
10x Genomics Chromium Single Cell Kit Version 3.1	10x Genomics
Nextera XT DNA Library Preparation Kit	Illumina	FC-131-1096
NovaSeq 6000 SP Flow Cell	Illumina	20028401
Deposited data
Raw and analyzed RNA-seq data	This study	GEO: GSE216643
Raw and analyzed ATAC-seq data	This study	GEO: GSE216643
Raw and analyzed scRNA-seq data	This study	GEO: GSE216643
Analyzed data of RNA-seq from the NeuroSeq atlas	Sugino et al.35	GEO: GSE79238
Analyzed data of RNA-seq–based expression in the DG upon stimulation and ATAC-seq	Sun et al.26 von Wittgenstein et al.28	GEO: GSE140180
Analyzed data of ATAC-seq upon kainic acid stimulation	Fernandez-Albert.et al.38	GEO: GSE125068
Analyzed data from Hipposeq	Cembrowski et al.39	GEO: GSE74985
Experimental models: Organisms/strains
Mouse: C57black6 Ola HSD	Harlan Laboratories	N/A
Mouse: Silc1−/− mice	Perry et al.9	N/A
Mouse: Silc1 loxP mice	This paper	N/A
Mouse: Silc1 polyA mice	This paper	N/A
Mouse: Sox11 loxP mice	Prof. Veronique Lefebvre lab	N/A
Mouse: C57black6 Ola HSD	Harlan Laboratories	N/A
Oligonucleotides
For a list of oligonucleotides used in this study see Table S4	This study	N/A
For a list of GapmerRs used in this study see Table S5	This study	N/A
Recombinant DNA
Silc1 pcDNA3.1(+) vector	Perry et al.9	N/A
pLenti-CMV-GFP-Sox11 vector	Addgene	120387
pENN.AAV.CamKII0.4.eGFP.WPRE.rBG	Addgene	105541
Software and algorithms
STAR	Dobin et al.69	https://github.com/alexdobin/STAR
RSEM	Li and Dewey70	https://deweylab.github.io/RSEM/
Cell Ranger 7.1.0	10x Genomics	https://support.10xgenomics.com/single-cell-gene-expression/
Bowtie2	Langmead and Salzberg71	https://bowtie-bio.sourceforge.net/bowtie2/index.shtml
Fiji (ImageJ) analysis software	NIH	https://fiji.sc/
IMARIS (v7.7.2) software	Oxford instruments	https://imaris.oxinst.com/
Other
Silc1 probes- RNAscope 2.5vs. probe ״Mm GM9866״	ACD	536709
Sox11 CDS probes- RNAscope 2.5vs. probe	ACD	440811
Sox11 3′UTR probes- RNAscope 2.5vs. probe	ACD	805071
Fos probes- RNAscope 2.5vs. probe	ACD	316921