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. 2023 Oct 25;18(13):865–880. doi: 10.2217/fvl-2023-0142

Figure 4. . Analysis of the inhibitory activity of the 1,4-disubstituted-1,2,3-triazole derivatives, 1 and 2, on Chikungunya virus egress.

Figure 4. 

Vero cells were infected with CHIKV BRA/RJ/18 (MOI = 1.0) and then treated with different compounds (100 μM) according to the top scheme. Infected and untreated cells (VC) or infected cells treated with DMSO (0.2%, vehicle control) or chloroquine (CQ, 100 μM) were used as controls. At 6 hpi, extracellular and intracellular contents were collected and titrated by plaque assays. Data are expressed as mean ± standard deviation (n = 3). Statistical significance was determined by ANOVA and Tukey post-test relative to VC group (for intracellular content, *p < 0.05; ****p < 0.0001; for the extracellular content, ####p < 0.0001).

CHIKV: Chikungunya virus; COMPD: Compound; CQ: Chloroquine; DMSO: Dimethyl sulfoxide; VC: Virus control.