Figure 6. . Prediction of molecular targets of the 1,4-disubstituted-1,2,3-triazole derivatives, 1, and 2.

(A) Structural similarity comparison between the triazole derivatives and proven ligands of Chikungunya virus proteins reported in the literature. The similarity was measured by the Tanimoto coefficient (Tc); Predicted binding mode and interactions of the compounds and similar known inhibitors with Chikungunya virus proteins: (B) nsP1 and (C) C protein. Hydrogen bonds and π-stacking interactions are represented as black and red dashed lines, respectively.

Compd: Compound.