Table 1. . Cytotoxicity and anti-CHIKV activity of the 1,4-disubstituted-1,2,3-triazole derivatives evaluated in this work and the control drug chloroquine (CQ).
| Compound | CHIKV 181/25 | CHIKV BRA/RJ/18 | ||||||
|---|---|---|---|---|---|---|---|---|
| BHK-21 | Vero | Vero | ||||||
| CC50 (μM) | EC50 (μM) | SI† | CC50 (μM) | EC50 (μM) | SI† | EC50 (μM) | SI† | |
| 1 | >1000 | >50 | ND | 466.6 ± 74.4 | >50 | ND | 19.9 ± 4.0 | 23.4 |
| 2 | 1053.2 ± 87.0 | 28.6 ± 3.6 | 36.9 | 211.1 ± 49.6 | 30.0 ± 1.3 | 7.1 | 19.7 ± 5.5 | 10.7 |
| CQ | 591.1 ± 62.4 | 18.8 ± 2.2 | 32.5 | 469.1 ± 84.4 | ND | ND | 47.5 ± 10.3 | 9,88 |
†
The selectivity index (SI) was calculated as the ratio between the CC50 and EC50 values.
CHIKV: Chikungunya virus; CQ: Chloroquine; ND: Not determined.